Current Grants:
- «Localization of RecN and RecA proteins in the cell during SOS response»
Principal Investigator: Natalia Morozova
Grant RSF
Duration: 2024–2026 - «Conformational states of the RAD51 recombinase»
Principal Investigator: Aleksandr Alekseev
Grant RSF
Duration: 2024–2026 - «Elucidation of molecular mechanisms of bacterial SMC-like complexes»
Principal Investigator: Aleksey Vedyajkin
Grant RSF
Duration: 2024–2027 - «Search for viral-origin membrane vesicles in giant bacteriophages that do not form a phage nucleus»
Principal Investigator: Daria Antonova
Grant RSF
Duration: 2025–2026 - «Study of molecular genetic mechanisms underlying neurological complications of acute respiratory viral infections and analysis of their consequences»
Principal Investigator: Andrey Vladimirovich Vasin
Government-funded research
Duration: 2024–2026
Completed Grants:
- «Provision of services for laboratory research aimed at developing a panel of molecular genetic biomarkers in peripheral blood for diagnosis and therapy monitoring of urolithiasis»
Principal Investigator: Mikhail Alekseevich Khodorkovsky
Service agreement with St. Petersburg GBUZ "St. Luke's Clinical Hospital"
Duration: 2024 - «Study of composition, structure and properties of nucleotide-binding proteins»
Principal Investigator: Mikhail Alekseevich Khodorkovsky
R&D agreement with LLC "NPF Sintol"
Duration: 2024 - «Development of a universal diagnostic platform based on CRISPR-Cas technologies for detection of infectious diseases»
Principal Investigator: Natalia Morozova
Priority 2030
Duration: 2022-2024 - «Search for small phage proteins with bactericidal activity»
Principal Investigator: Mikhail Alekseevich Khodorkovsky
Research Contract with Lomonosov Moscow State University, Faculty of Biology under RSF grant No. 24-44-02003 dated 20.03.2024. Title: «Functional and structural approaches to enhance selection and design of bacteriophages for antibacterial therapy applications»
Duration: 2024 - «Study of the mechanisms of action of RecN protein — a cohesin-like component of bacterial SOS response»
Principal Investigator: Natalia Morozova
Grant RSF
Duration: 2022–2024 - «Development of novel antibacterial compounds based on phage proteins»
Principal Investigator: Maria Yakunina
Priority 2030
Duration: 2022-2023 - «Determination of NAD and its metabolites concentration in biological samples by NMR spectroscopy»
Contract with the Institute of Natural Sciences, Russian Academy of Sciences (INZ RAN) under RSF grant No. 21-14-00319
Title: «The role of NAD in regulating pluripotency and differentiation of mouse embryonic stem cells»
Duration: 2021-2023 - «Role of mobile genetic elements in the evolution of CRISPR-Cas systems»
Principal Investigator: Alexander Yakimov
Grant RSF
Duration: 2021–2023 - «Search for novel mechanisms regulating bacterial cell division during SOS response»
Principal Investigator: Alexey Vedyaykin
Grant RSF
Duration: 2022–2023 - «Fluorescence visualization of intracellular structures with molecular resolution»
Principal Investigator: Alexey Vedyaykin
Presidential grant (Russian Federation)
Duration: 2022–2023 - «Development of novel genome editing tools for eukaryotic cells»
Principal Investigator: Mikhail Alekseevich Khodorkovsky
Contract: Institute of Bioorganic Chemistry, Russian Academy of Sciences (IBCh RAS)
Duration: 2020–2022 - «Non-canonical functions of the CRISPR-Cas system in Clostridioides difficile»
Principal Investigator: Anna Maykova
Grant: Presidential grant (Russian Federation)
Duration: 2021–2022 - «Regulatory factors of the CRISPR-Cas system in pathogenic bacterium Clostridioides difficile»
Principal Investigator: Anna Maykova
Grant RSF
Duration: 2020–2022 - «Study of pathogenic bacterial cell infection by giant bacteriophage phiKZ»
Principal Investigator: Maria Yakunina
Grant RSF
Duration: 2019–2022 - «Molecular mechanisms of RecA protein regulation, the activator of bacterial SOS response»
Principal Investigator: Egor Pobegalov
Grant RSF
Duration: 2019–2022 - «Regulation of transcription by molecular barriers of various nature»
Principal Investigator: Mikhail Alekseevich Khodorkovsky
Funding: Ministry of Science and Higher Education of the Russian Federation
Duration: 2021 - «Determination of division mechanisms in 'minimal' bacteria lacking the key division protein FtsZ»
Principal Investigator: Alexey Vedyaykin
Grant RFBR (Russian Foundation for Basic Research)
Duration: 2020–2021 - «Development and validation of bioanalytical methods for drug determination in physiological fluids and tissues»
Principal Investigator: Mikhail Alekseevich Khodorkovsky
Contract: "Analytical Spectrometry Core Facility"
Duration: 2017–2020 - «Identification of mycoplasma proteins from cell extracts by co-precipitation using mass spectrometric analysis»
Contract with INZ RAS under RSF grant No. 17-74-20065
Title: "Stress proteins and bacterial cytoskeletal proteins of mycoplasmas - pathogens of agricultural plants and animals as virulence and persistence factors, and potential targets for controlling mycoplasma infections"
Duration: 2019 - «AAV-delivered nucleases for next-generation gene therapy drugs targeting inherited disorders»
Principal Investigator: Mikhail Alekseevich Khodorkovsky
Contract: Skoltech, under Agreement No. 14.606.21.0006 (Federal Target Program "Research and Development")
Duration: 2017–2019 - «Permanent research staff»
Principal Investigators: Tatiana Artamonova, Egor Pobegalov, Alexey Vedyaykin
Funding: State Assignment
Duration: 2017–2019 - «Permanent senior researchers»
Principal Investigator: Mikhail Alekseevich Khodorkovsky
Funding: State Assignment
Duration: 2017–2019 - «Structure and properties of the unique non-virion RNA polymerase of bacteriophage phiKZ»
Principal Investigator: Maria Yakunina
Grant: RSF (Russian Science Foundation)
Duration: 2017–2019 - «Regulation mechanisms of the mitochondrial NAD pool in human cells»
Principal Investigator: Veronika Kulikova
Grant: RSF (Russian Science Foundation)
Duration: 2018–2020 - «Studies of intramolecular transitions»
Principal Investigator: Alexey Melnikov
Funding: State Assignment
Duration: 2017–2019 - «Identification of mycoplasma and Escherichia coli proteins from cell extracts using co-immunoprecipitation and co-precipitation methods with mass spectrometric analysis»
Contract with INZ RAS under RSF grant No. 17-74-20065
Title: "Stress proteins and bacterial cytoskeletal proteins of mycoplasmas - pathogens of agricultural plants and animals as virulence/persistence factors and potential targets for controlling mycoplasma infections"
Duration: 2018 - «Quantitative analysis of NAD and its major metabolites in extracts from cultured human cells, as well as in mouse organs and tissues by NMR spectroscopy»
Principal Investigator: Sergey Vadimovich Murashov
Contract: Institute of Natural Sciences, RAS (INZ RAS) under RSF grant "New vitamin B3 derivatives: molecular mechanisms of action and potential therapeutic effects"
Duration: 2018 - «Study of physicochemical properties of peptides by nuclear magnetic resonance using Varian DirectDrive NMR System 700 MHz»
Contract with NRC "Kurchatov Institute" - PNPI
Duration: 2018 - «Experimental validation of a technology development concept for suppressing donor cell rejection by manipulating major histocompatibility complex genes»
Principal Investigator: Sergey Vadimovich Murashov
Funding: State Assignment
Duration: 2018 - «Study of substrate specificity of lasso peptide synthetases and their structural characterization»
Principal Investigators: Mikhail Metelev / Tatiana Zyubko
Grant: RFBR (Russian Foundation for Basic Research)
Duration: 2016–2018 - «Quantitative analysis of NAD and its major metabolites in extracts from cultured human cells and mouse organs/tissues by NMR spectroscopy»
Principal Investigator: Sergey Vadimovich Murashov
Contract: Institute of Natural Sciences, RAS (INZ RAS) under RSF grant "New vitamin B3 derivatives: molecular mechanisms of action and potential therapeutic effects"
Duration: 2017 - «Optimization of NMR spectroscopy method for quantitative analysis of NAD metabolites and ATP in extracts from cultured human cells and mouse organs/tissues»
Principal Investigator: Sergey Vadimovich Murashov
Contract: Institute of Natural Sciences, RAS (INZ RAS) under RSF grant "New vitamin B3 derivatives: molecular mechanisms of action and potential therapeutic effects"
Duration: 2016 - «Development and study of next-generation antibacterial peptides with significantly improved properties based on genetically modified microcins»
Principal Investigator: Konstantin Severinov
Contract: Skolkovo Institute of Science and Technology (Skoltech)
Duration: 2014–2015 - «Support of scientific research»
Principal Investigator: Mikhail Alekseevich Khodorkovsky
Funding: State Assignment
Duration: 2014–2016 - «Research support»
Principal Investigators: Tatiana Artamonova, Egor Pobegalov, Alexander Grigoriev
Funding: State Assignment
Duration: 2014–2016 - «Non-canonical multisubunit RNA polymerases of giant bacteriophage phiKZ»
Principal Investigator: Maria Yakunina
Grant: RFBR (Russian Foundation for Basic Research)
Duration: 2016–2017 - «Mechanisms of action of exogenous NAD and its key metabolites as efficient precursors of intracellular NAD»
Principal Investigator: Alexander Yakimov
Grant: RFBR (Russian Foundation for Basic Research)
Duration: 2016–2017 - «Study of formation mechanisms and interactions between extra- and intracellular pools of nicotinamide and nicotinic acid ribosides - potential therapeutic agents for treating neurodegenerative diseases and pathologies associated with metabolic disorders»
Principal Investigator: Veronika Kulikova
Funding: Presidential Scholarship for Young Scientists and PhD Students (Russia)
Duration: 2015–2017 - «Study of molecular mechanisms of FtsZ protein function as a promising target for developing novel highly effective antibacterial drugs»
Principal Investigator: Alexey Vedyaykin
Funding: Presidential Scholarship for Young Scientists and PhD Students (Russia)
Duration: 2015–2017 - «Molecular, ecological and applied microbiology»
Resolution of the Government of the Russian Federation No. 220
"On measures to attract leading scientists to Russian higher education institutions" (megagrant)
Duration: 2013–2017 - «Study of mechanisms and dynamics of nucleotide-binding proteins: from bacteria to humans»
Principal Investigator: Mikhail Alekseevich Khodorkovsky
Grant RSF
Duration: 2014–2016 - «Comprehensive study of NAD biosynthesis pathways in human cells»
Principal Investigator: Andrey Nikiforov
Grant RFBR
Duration: 2014–2016 - «Identification and functional characterization of novel antibacterial lasso peptides»
Grant: Dynasty Foundation
Duration: 2015 - «Microbiology, Proteomics, Pharmacology»
Project (510-02) 0-20
Duration: 2014–2015 - «Study of potential role of human cytosolic 5'-nucleotidases in NAD metabolism»
Grant: RFBR (Russian Foundation for Basic Research)
Duration: 2014–2015 - «Study of mechanisms of eukaryotic TIP49 proteins function»
Grant: RFBR (Russian Foundation for Basic Research)
Duration: 2014–2015 - «Visualization of proteins in single-molecule biophysical experiments using novel triplet luminophores based on polynuclear transition metal complexes»
Grant: RFBR (Russian Foundation for Basic Research)
Duration: 2013–2015 - «Single-molecule studies of DNA-binding properties of prospective protein targets for hepatocellular carcinoma therapy»
Funding: Presidential Scholarship for Young Scientists and PhD Students (Russia)
Duration: 2013–2015 - «Single-molecule studies of DNA-binding ATPases Pontin and Reptin using optical tweezers»
Grant: OPTEC company (support for young scientists from leading universities and research centers)
Duration: 2013 - «Study of formation mechanisms and interactions between intra- and extracellular pools of key NAD metabolites»
Grant: RFBR (Russian Foundation for Basic Research)
Duration: 28.11.2012–31.12.2013 - «Single-molecule studies of DNA substrate properties upon binding with TIP49 proteins»
Grant: RFBR (Russian Foundation for Basic Research)
Duration: 08.11.2012–31.12.2013 - «Study of structures formed by FtsZ protein in Mycoplasma hominis cells using localization microscopy»
Grant: RFBR (Russian Foundation for Basic Research)
Duration: 08.11.2012–31.12.2013 - «Role of domains and interdomain linkers in actin filament regulation by villin family proteins»
Research work within the Federal Target Program 'Scientific and Scientific-Pedagogical Personnel of Innovative Russia' for 2009-2013, Measure 1.5, Lot 'Support for scientific research conducted by teams under the direction of invited researchers in the scientific field Life Sciences (Living Systems)' in the following areas: - Biocatalytic, biosynthetic and biosensor technologies, - Genomic, proteomic and post-genomic technologies, - Cellular technologies, - Bioengineering"
Duration: 17.09.2012–15.11.2013 - «Transcriptional control during Pseudomonas aeruginosa infection by giant φKZ-like phages»
Research work within the Federal Target Program 'Scientific and Scientific-Pedagogical Personnel of Innovative Russia' for 2009-2013, Measure 1.5, Lot 'Support for scientific research conducted by teams under the direction of invited researchers in the scientific field Biology, Medicine' in the following areas: - General biology and genetics, - Physical-chemical molecular and cellular biology"
Duration: 10.09.2012–15.11.2013 - «Conducting research in the field of living systems by the Analytical Center for Nano- and Biotechnology of SPbSPU through development of diagnostic methods for composition, structure and properties of biologically active compounds»
Research work within the Federal Target Program 'Research and Development in Priority Areas of Russia's Science and Technology Complex for 2007-2013', Measure 5.2, Lot 'Provision of equipment sharing centers for comprehensive research in priority areas of science, technology and engineering in the Russian Federation'"
Duration: 11.07.2012–21.07.2013 - «Study of mechanical properties of cell membranes using optical trapping with a unique integrated setup for single-molecule level studies of nanobiomachine dynamics (facility code 'Laser Tweezers')»
Research work within the Federal Target Program 'Research and Development in Priority Areas of Russia's Science and Technology Complex for 2007-2012', Measure 1.8, Lot 'Conducting research using unique test benches and facilities in the priority area Life Sciences'"
Duration: 20.07.2012–25.07.2013 - «Study of ATP-dependent oligomerization dynamics of TIP49 family proteins on individual DNA molecules»
Research work within the Federal Target Program 'Research and Development in Priority Areas of Russia's Science and Technology Complex for 2007-2013', Measure 1.9, Lot 'Problem-oriented exploratory research and creation of scientific-technical foundation in the priority area Living Systems with participation of scientific and research organizations from European Union countries'"
Duration: 18.08.2011–08.05.2013 - «Conducting research in the field of living systems through development of super-resolution fluorescence microscopy methods using a unique integrated setup for single-molecule level studies of nanobiomachine dynamics" (facility code "Laser Tweezers")»
Research work within the Federal Target Program 'Research and Development in Priority Areas of Russia's Science and Technology Complex for 2007-2012', Measure 1.8, Lot 'Conducting research using unique test benches and facilities in the field of living systems'"
Duration: 11.05.2011–16.11.2012 - «Proteomic analysis of human secreted nanostructures (exosomes) produced by normal and oncologically transformed cells»
Research work within the Federal Target Program 'Scientific and Scientific-Pedagogical Personnel of Innovative Russia' for 2009-2013, Measure 1.1, Lot 'Conducting scientific research by teams of scientific-educational centers under the project Human Proteome'"
Duration: 29.11.2010–15.11.2012 - «Conducting research in the field of living systems by the Analytical Center for Nano- and Biotechnology of SPbSPU through development of diagnostic methods for composition, structure and properties of biologically active compounds»
Research work within the Federal Target Program 'Research and Development in Priority Areas of Russia's Science and Technology Complex for 2007-2013', Measure 5.2, Lot 'Conducting research by equipment sharing centers within main directions of the Federal Target Program "Research and Development in Priority Areas of Russia's Science and Technology Complex for 2007-2013"'"
Duration: 29.07.2011–06.08.2012 - «Study of formation mechanisms of carbon-containing micro- and nanostructures during co-carbonization of plant polymers, liquid hydrocarbons and coal-derived arenes»
Research work within the Federal Target Program 'Scientific and Scientific-Pedagogical Personnel of Innovative Russia' for 2009-2013, Measure 1.5, Lot 'Conducting scientific research by teams under the direction of invited researchers in the field of chemistry and new materials'"
Duration: 12.03.2010–15.11.2010 - «Study of DNA conformational change dynamics induced by chromatin remodeling factors using optical tweezers ('laser tweezers') and molecular modeling methods»
Research work within the Federal Target Program 'Scientific and Scientific-Pedagogical Personnel of Innovative Russia' for 2009-2013, Measure 1.5, Lot 'Conducting scientific research by teams under the direction of invited researchers in the following areas: - biology, agricultural sciences and living systems technologies; - medicine; - Earth sciences, ecology, sustainable environmental management'"
Duration: 10.06.2010–15.11.2011 - «Conducting research in the field of living systems using a laser-optical system for analyzing the functioning of 3D nanosystems, which is part of the unique integrated setup for studying nanobiomachine dynamics" (facility code "Laser Tweezers"»
Research work within the Federal Target Program 'Research and Development in Priority Areas of Russia's Science and Technology Complex' for 2007-2012, Lot 'Conducting research in the field of living systems using unique facilities'"
Duration: 08.08.2009–30.11.2010 - «Study of mutual influence of charge transfer and kinetic energy of neutral fullerene molecules on surface nanostructure formation»
Grant: RFBR (Russian Foundation for Basic Research)
Duration: 2008–2010 - «Mass spectrometric identification of regulatory cellular proteins of phosphatase PP1 involved in human immunodeficiency virus (HIV) replication»
Research work within the Federal Target Program 'Scientific and Scientific-Pedagogical Personnel of Innovative Russia' for 2009-2013, Measure 1.5, Lot 'Conducting scientific research by teams under the direction of invited researchers in the field of medicine'
Duration: July 2009–August 2010 - «Structural proteomics of redox proteins involved in regulation of oxidative stress consequences»
Research work within the Federal Target Program 'Scientific and Scientific-Pedagogical Personnel of Innovative Russia' for 2009-2013, Measure 1.5, Lot 'Conducting scientific research by teams under the direction of invited researchers in the field of biology, agricultural sciences and living systems technologies'
Duration: July 2009–August 2010 - «Development of a model and study of noble gas nanocomplexes for use in laser systems with participation of Swedish scientific organizations»
Research work within the framework of the Federal Target Program “Research and Development in Priority Areas of Development of the Scientific and Technological Complex of Russia” for 2007–2012
Duration: October 2009–September 2010